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Writer's pictureCheng Her, MD, MS, IFMCP

Mitochondria: How Do They Impact Your Overall Health?


When you think back to your high school biology days, you might remember that mitochondria were called the “powerhouses of the cell.” While that may have seemed like just a fun fact back then, it’s actually the key to understanding your health today. Mitochondria are tiny yet powerful structures inside nearly every cell in your body (except red blood cells), and they work tirelessly to produce the energy that keeps you going—whether you’re tackling your to-do list or simply getting out of bed in the morning.


Each cell can have hundreds or even thousands of mitochondria, depending on how much energy it needs to function. Your heart, brain, liver, and immune cells—parts of your body that are constantly at work—are especially rich in mitochondria. Just like your phone needs a fully charged battery to run smoothly, your body needs healthy mitochondria to keep you feeling energized and well.


How Mitochondria Produce Energy


Every single day, your body needs energy to power everything you do, from laughing with friends to healing after an illness. Mitochondria create this energy through a process called oxidative phosphorylation. This process may sound complicated, but at its core, it’s all about making ATP, the main source of energy your cells use. This process relies on oxygen, and when your mitochondria can’t produce enough energy, it affects how your cells—and you—feel.


When energy production is compromised, you might notice persistent fatigue, slower recovery, or being more prone to getting sick. These signs are your body’s way of telling you it needs extra support.


What Is Mitochondrial Dysfunction?


Mitochondrial dysfunction occurs when these energy-producing powerhouses don’t work as well as they should. This can be due to:


- Unhealthy dietary and lifestyle choices

- Exposure to environmental toxins

- Infections

- Certain medications


These factors can damage mitochondrial DNA and proteins, which leads to reduced energy production. During energy production, mitochondria naturally create free radicals. Healthy mitochondria balance this with antioxidants to keep cells protected. But when mitochondria are struggling, they may not keep up with this balance, leading to oxidative stress and making you feel unwell.


Conditions Associated with Mitochondrial Dysfunction


Mitochondrial dysfunction doesn’t just drain your energy—it can be linked to various health challenges, such as:


Chronic Fatigue Syndrome (CFS/ME): Persistent and debilitating fatigue that doesn’t improve with rest and is often accompanied by cognitive difficulties, pain, and sleep disturbances.


Neurodegenerative Disorders:


Alzheimer’s Disease: Characterized by memory loss, cognitive decline, and behavioral changes; mitochondrial dysfunction can contribute to the accumulation of beta-amyloid plaques and oxidative stress.


Parkinson’s Disease: Marked by tremors, stiffness, and slowed movements; mitochondrial impairment can lead to the loss of dopaminergic neurons and increased oxidative damage.


Amyotrophic Lateral Sclerosis (ALS): A progressive neurodegenerative disorder that affects motor neurons, leading to muscle weakness and atrophy.


Neuropathic Pain: Chronic pain resulting from nerve damage or dysfunction, potentially linked to impaired mitochondrial function and heightened oxidative stress.


Migraines: Severe, recurring headaches that can include symptoms such as nausea, sensitivity to light, and visual disturbances; mitochondrial dysfunction can contribute to the energy deficits seen in migraine-prone individuals.


Metabolic Diseases:


Type 2 Diabetes: Mitochondrial dysfunction can play a role in insulin resistance and impaired glucose metabolism.


Obesity: Associated with reduced mitochondrial biogenesis and function, impacting the body’s energy balance and metabolic health.


Cardiovascular Diseases: Conditions like heart failure and cardiomyopathy can be linked to reduced mitochondrial function, which affects the heart’s ability to generate energy.


Fibromyalgia: A condition marked by widespread musculoskeletal pain, fatigue, and cognitive issues, potentially related to mitochondrial dysfunction and reduced cellular energy.


Autoimmune Disorders:


Multiple Sclerosis (MS): An immune-mediated condition affecting the central nervous system, with research suggesting mitochondrial damage may contribute to nerve cell degeneration.


Lupus (SLE): An autoimmune disease that can cause widespread inflammation; mitochondrial dysfunction can exacerbate oxidative stress and cellular damage.


Muscular Dystrophies: Genetic conditions, such as Duchenne Muscular Dystrophy, where mitochondrial dysfunction can lead to progressive muscle weakness and degeneration.


These examples show just how significant mitochondrial health is in maintaining your overall well-being.


How to Support Your Mitochondria


The great news is that there are caring, proactive ways to support your mitochondria and boost your overall health:


- Embrace regular, moderate physical activity

- Prioritize restful, quality sleep

- Consider intermittent fasting to promote cellular health

- Focus on a diet rich in antioxidant-packed foods, such as colorful fruits and vegetables


Certain supplements, like CoQ10, acetyl-L-carnitine, NAC, and alpha-lipoic acid, can also help enhance mitochondrial function.


Beyond that, taking steps to reduce exposure to toxins, addressing chronic infections, and being mindful of medication use can help protect and nurture your mitochondria.


The Bottom Line


Your mitochondria are essential to your well-being. When they are supported and functioning well, they help you stay energized, resilient, and better equipped to handle life’s demands. When they struggle, it can manifest as fatigue, frequent illness, or other health issues. By making thoughtful changes and giving your mitochondria the care they need, you can take meaningful steps toward feeling better and more vibrant.


Let’s Get Started


If you’re ready to start feeling more energized and confident in your health, know that we’re here for you. At Telos Functional and Integrative Medicine LLC, we’re committed to supporting you every step of the way. Schedule your complimentary discovery call today, and let’s work together on a personalized plan that optimizes your mitochondrial health and boosts your energy.


Your well-being is important to us, and we’re here to guide you on your path to greater energy and health.

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